Open PhD Position


Posted on October 18, 2017




Inferring genomic information from bisulfite sequencing data



Background

DNA methylation variants can arise spontaneously, they can be under genetic control or they can be induced by the environment. In plants, some DNA methylation variants are stable across many generations whereas other variants are very transient. A good understanding of the transgenerational dynamics of DNA methylation variants is essential to understand their impact on heritable traits and their effect on adaptation. Current insight in the transgenerational dynamics of DNA methylation is limited to very few model plant species, but it is predicted that these dynamics are not constant among different plants. For instance, plant reproduction mode can have a large effect because asexual reproduction bypasses some of the epigenetic resetting mechanisms that normally occur during sexual reproduction. Adaptive differences in transgenerational stability may also differ between species with different life spans or from habitats of different environmental predictability.

Your PhD Project

In this project, we aim to investigate differences in DNA methylation dynamics between species with different life history traits. In close collaboration with other bioinformaticians and biologists, a best-practice pipeline for the analysis of plant bisulfite data will be developed, benchmarked, and provided to be applied to the Next-Generation Sequencing (NGS) data generated in the frame of different EpiDiverse projects. In addition, novel algorithms will be devised and implemented to better detect DNA methylation variants and search for important methylation haplotypes to better understand the epigenetic regulation. The special constellation of working at a bioinformatics company in very strong cooperation with the chair of bioinformatics at the university offers the unique possibility of gaining benefits from both: The clearly structured style of the work in a company will help implementing novel ideas from academia in the light of recent publications, resulting in a strong focus and high productivity.

Your Qualifications

We seek a bright, highly motivated, and enthusiastic bioinformatician, or computer scientist with significant interest in solving biologically motivated questions. Excellent programming skills with knowledge of at least one of the following programming languages are mandatory: Python, R, or C/C++/C#. A strong background in Next-Generation Sequencing (NGS) and/or (epi)genetics data analyses are an advantage. A high standard of spoken and written English is required, as are good quantitative and analytical capabilities, excellent interpersonal and communication skills, and the ability to work independently as well as part of a team.

How to apply

You may apply by providing a letter of motivation, a detailed CV and contact information of up to three references, all as a single pdf file!

Send the file by email:

  • to: info@epidiverse.eu
  • Cc: support@ecseq.com
  • Subject: EpiDiverse-Application RP-3

If you have questions, you can contact support@ecseq.com.

Keydates

  • Application deadline: 24 November 2017
  • Interviews: December 2017
  • Starting date: 1 April 2018

About EpiDiverse

EpiDiverse - Epigenetic Diversity in Ecology - is a Marie Skłodowska-Curie Innovative Training Network aimed at the study of epigenetic variation in wild plant species. This network joins academic groups from ecology, molecular (epi)genetics and bioinformatics with life science companies to explore epigenetic mechanisms and their adaptive relevance in natural plant populations.



The cross-disciplinary research program investigates how epigenetic mechanisms, in interaction with environments and transposable elements, contribute to variation that is relevant for the adaptive capacity of plants. By applying epigenomic research tools to a selection of different wild plants (including long-lived trees, annual and asexually reproducing species) we investigate how epigenetic mechanisms as well as their ecological relevance differs between plant species. Understanding the epigenetic contribution to adaptive capacity will help to predict species responses to global warming and can open new directions for sustainable agriculture and crop breeding.

The EpiDiverse consortium will train 15 Early Stage Researchers to become expert eco-epigeneticists, equipping them with the interdisciplinary skills - molecular, (epi)genomic, ecological and bioinformatics - to successfully tackle this new research area. EpiDiverse training will emphasize empirical and informatics skills to become fluent and creative in extracting knowledge from big ‘omics data in natural contexts.

EpiDiverse is funded by the EU Horizon 2020 programme and involves 12 partners from academia, non-profit organizations and industry located in the Netherlands, Germany, France, Spain, Czech Republic, Italy and Austria.

For further Information check the official website of EpiDiverse.




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